Prilocaine is biotransformed in which organs?

Prilocaine is biotransformed in which organs?

• A. Only Liver
• B. Liver, Kidneys, and Lungs
• C. Only Kidneys
• D. Brain

Answer: (B)

Biotransformation of prilocaine occurs in multiple organs, not just the liver. While the liver is the primary site where many drugs are metabolized, prilocaine also undergoes significant metabolism outside the liver, particularly in the kidneys and the lungs as the drug circulates. The liver uses hepatic enzymes to convert prilocaine to metabolites such as o-toluidine, and portions of the drug and its metabolites are handled by renal pathways and pulmonary enzymes. Because of this, the most accurate answer includes all three organs. The brain isn’t a meaningful site of prilocaine metabolism, since it doesn’t provide the main enzymatic systems used for this drug.

Biotransformation of prilocaine occurs in multiple organs, not just the liver. While the liver is the primary site where many drugs are metabolized, prilocaine also undergoes significant metabolism outside the liver, particularly in the kidneys and the lungs as the drug circulates. The liver uses hepatic enzymes to convert prilocaine to metabolites such as o-toluidine, and portions of the drug and its metabolites are handled by renal pathways and pulmonary enzymes. Because of this, the most accurate answer includes all three organs. The brain isn’t a meaningful site of prilocaine metabolism, since it doesn’t provide the main enzymatic systems used for this drug.